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Being able to model the disease from a single cell all the way up to heart tissue, I think that's a big advance, explained Kevin Kit Parker from Harvard University's Wyss Institute for Biologically Inspired Engineering. The researchers took skin cells from two Barth syndrome patients and manipulated the cells to become stem cells that carried these patients' TAZ mutations. Instead of using the stem cells to generate single heart cells in a dish, the cells were grown on chips lined with human extracellular matrix proteins that mimic their natural environment - tricking the cells into joining together as they would if they were forming a diseased human heart. The engineered diseased tissue contracted very weakly, as would the heart muscle seen in Barth syndrome patients. The investigators then used genome editing to mutate TAZ in normal cells. On the other hand, delivering the TAZ gene product to diseased tissue in the laboratory corrected the contractile defect, creating the first tissue-based model of correction of a genetic heart disease. Whether that can be achieved in an animal model or a patient is a different story, but if that could be done, it would suggest a new therapeutic angle, said Harvard scientist William Pu. Their work has been published in the journal Nature Medicine. --Indo-Asian News Service na/rd( 347 Words)2014-05-12-10:54:18 (IANS) d sunglasses for cheap “It’s almost shameful. ... way underfunded.â€Nearly all of the Russellville City Council and Finance Committee members who discussed elected officials’ salaries agreed the annual mayor’s salary — less than $49,900 — should be higher.All except one alderman who has already announced his candidacy for mayor.“I can’t imagine why anyone on Earth couldn’t make a living†on that salary, Alderman Martin Irwin said, adding that he felt department heads should make more than the mayor because of their professional backgrounds, plus the fact the mayor depends on department heads for various tasks.Finance Committee Chairman Randall Horton explained he read a survey of executive managers who employed more than 100 people whose annual salary averaged nearly $300,000.“I like where this is going,†Mayor Bill Eaton joked.Alderman Mark Tripp said most department heads make more than the mayor, and the annual salary should be $60,000 to $80,000. 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